Table 1 Model parameters. For consistency, all values are given in three significant digits
From: An empirical model for educational simulation of cervical dilation in first-stage labor
Symbol | Description | Value | Unit | Reference |
|---|---|---|---|---|
P1 | Baseline oxytocin release rate in hypothalamus | 0.740 | mU/min | [7] |
P2 | Gain from cervical dilation to oxytocin release rate in hypothalamus | 50.0 | mU/(min cm) | |
P3 | Pharmacokinetic parameter: Elimination rate constant | 0.0693 | 1/min | [3] |
P4 | Pharmacokinetic parameter: Volume of distribution | 18,700 | mL | |
P5 | Maximal concentration frequency | 0.500 | 1/min | [2] |
P6 | Pharmacodynamic parameter: Oxytocin concentration resulting in 50% effect | 7.90 | mU/mL | [3] |
P7 | Pharmacodynamic parameter: Slope of sigmoidal curve | 1.11 | dimensionless | [2] |
P8 | Baseline contraction amplitude | 40.0 | mm Hg | [10] |
P9 | Maximal contraction amplitude | 40.0 | mm Hg | [2] |
P10 | Dilation increase due to pressure exerted by the fetus on the cervix | 1.00 × 10−3 | cm/min | [11] |
P11 | Dilation increase due to contraction frequency and amplitude | 1.90 × 10−2 | cm/mm Hg |